When it comes to prescription weight loss medications, most people have heard of Semaglutide—known by brand names like Ozempic® and Wegovy®. But there’s a new name gaining attention: Tesofensine.
So how do they compare? And which one might be a better fit for your weight loss journey?
Let’s break it down.
What Is Semaglutide?
Semaglutide is a GLP-1 receptor agonist originally used to treat type 2 diabetes. It helps with weight loss by:
- Slowing down digestion
- Reducing appetite
- Stabilizing blood sugar
- Increasing feelings of fullness
It’s FDA-approved for weight loss under the brand name Wegovy and is typically given as a weekly injection.
What Is Tesofensine?
Tesofensine is a once-daily oral medication that works differently. It’s a triple reuptake inhibitor—meaning it increases levels of dopamine, norepinephrine, and serotonin in the brain. These neurotransmitters help:
- Suppress appetite
- Improve satiety (feeling full)
- Support energy and mood
Tesofensine is not yet FDA-approved for weight loss in the U.S., but it’s being used off-label with promising results.
Key Differences: Tesofensine vs. Semaglutide
| Feature | Tesofensine | Semaglutide |
|---|---|---|
| How It’s Taken | Oral pill (daily) | Weekly injection |
| Mechanism of Action | Affects brain chemicals to reduce appetite | Mimics a hormone that slows digestion |
| Common Side Effects | Dry mouth, slight insomnia | Nausea, constipation, fatigue |
| Time to Notice Results | Fast (often within 1 week) | Gradual (weeks to months) |
| FDA Status for Weight Loss | Off-label in U.S. | Approved (Wegovy) |
| Insurance Coverage | Not usually covered | May be covered with prior authorization |
Why Some Patients Prefer Tesofensine
- No injections – Easy-to-take pill form
- Less nausea – No impact on the digestive tract
- Fast appetite suppression – Many patients feel results in just days
- Alternative for low BMI patients – Especially for those who don’t qualify for GLP-1 coverage
Why Some Patients Prefer Semaglutide
- Proven track record – Clinically studied and FDA-approved
- Improves blood sugar – Ideal for patients with prediabetes or type 2 diabetes
- Insurance help – May be covered under certain plans
Which One Is Right for You?
The best choice depends on your:
- Weight loss goals
- Medical history
- Tolerance for side effects
- Insurance coverage
- Preference for pills vs. injections
At Bridgeside Telehealth, our medical providers help you weigh the pros and cons of each option—and tailor a plan just for you.
